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Table of Contents
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1
A Brief History of Epigenetics 1
Gary Felsenfeld
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2
The Next Generation: Young Scientists Forging Exciting New Discoveries in Epigenetic Research 11
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3
Overview and Concepts 47
C. David Allis, Marie-Laure Caparros, Thomas Jenuwein, Monika Lachner, and Danny Reinberg
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4
Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition 117
Ronen Marmorstein and Ming-Ming Zhou
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5
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes 143
Edward Seto and Minoru Yoshida
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6
Structural and Functional Coordination of DNA and Histone Methylation 169
Xiaodong Cheng
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7
A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks 193
Dinshaw J. Patel
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8
Epigenetics in Saccharomyces cerevisiae 241
Michael Grunstein and Susan M. Gasser
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9
Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe 269
Robin C. Allshire and Karl Ekwall
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10
Neurospora crassa, a Model System for Epigenetics Research 295
Rodolfo Aramayo and Eric U. Selker
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11
Epigenetics of Ciliates 313
Douglas L. Chalker, Eric Meyer, and Kazufumi Mochizuki
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12
Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila 337
Sarah C.R. Elgin and Gunter Reuter
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13
Epigenetic Regulation in Plants 363
Craig S. Pikaard and Ortrun Mittelsten Scheid
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14
The Use of Mouse Models to Study Epigenetics 395
Marnie Blewitt and Emma Whitelaw
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15
DNA Methylation in Mammals 423
En Li and Yi Zhang
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16
RNAi and Heterochromatin Assembly 445
Robert Martienssen and Danesh Moazed
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17
Transcriptional Silencing by Polycomb-Group Proteins 463
Ueli Grossniklaus and Renato Paro
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18
Transcriptional Regulation by Trithorax-Group Proteins 489
Robert E. Kingston and John W. Tamkun
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19
Long-Range Chromatin Interactions 507
Job Dekker and Tom Misteli
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20
Histone Variants and Epigenetics 529
Steven Henikoff and M. Mitchell Smith
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21
Nucleosome Remodeling and Epigenetics 555
Peter B. Becker and Jerry L. Workman
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22
Maintenance of Epigenetic Information 575
Genevive Almouzni and Howard Cedar
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23
Regulation of the X Chromosomes in Caenorhabditis elegans 599
Susan Strome, William G. Kelly, Sevinc Ercan, and Jason D. Lieb
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24
Dosage Compensation in Drosophila 621
John C. Lucchesi and Mitzi I. Kuroda
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25
Dosage Compensation in Mammals 641
Neil Brockdorff and Bryan M. Turner
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26
Genomic Imprinting in Mammals 667
Denise P. Barlow and Marisa S. Bartolomei
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27
Germline and Pluripotent Stem Cells 687
Wolf Reik and M. Azim Surani
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28
Induced Pluripotency and Epigenetic Reprogramming 711
Konrad Hochedlinger and Rudolf Jaenisch
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29
Epigenetic Control of Immunity 737
Meinrad Busslinger and Alexander Tarakhovsky
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30
Metabolic Signaling to Chromatin 763
Shelley L. Berger and Paolo Sassone-Corsi
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31
Epigenetic Regulation in Plant Responses to the Environment 787
David C. Baulcombe and Caroline Dean
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32
Histone and DNA Modifications as Regulators of Neuronal Development and Function 807
Stavros Lomvardas and Tom Maniatis
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33
Epigenetics and Human Disease 831
Huda Y. Zoghbi and Arthur L. Beaudet
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34
Epigenetic Determinants of Cancer 859
Stephen B. Baylin and Peter A. Jones
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35
Histone Modifications and Cancer 895
James E. Audia and Robert M. Campbell
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36
The Necessity of Chromatin: A View in Perspective 927
Vincenzo Pirrotta